Deep Principle

Hangzhou AI-for-science company building AI scientists and open models for chemistry and materials discovery

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About

Deep Principle is a Hangzhou-based AI-for-science company combining generative AI with first-principles calculations to accelerate materials and chemical R&D. It builds Mira, an AI scientist platform for literature analysis, experiment design, data analysis and long-running research tasks. On 2 November 2026 it released Hydrogen-1.0, an MIT-licensed open-weight scientific model post-trained from GLM-5.3 on chemistry, materials science and life sciences data plus records and agent trajectories from its own laboratories.

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  • Hydrogen-1.0 — 753B-parameter open-weight scientific model for chemistry, materials science and life sciences · Open Source
  • Mira — AI scientist platform for literature analysis, experiment design and autonomous research · Saas

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