Small-molecule TrkB neuroplastogens for mental health and neurodegeneration
Kasvu Therapeutics develops selective small-molecule TrkB positive allosteric modulators designed to promote neuroplasticity without hallucinogenic 5-HT2A activity. Its lead candidate KTX-0141 is advancing through IND/CTA-enabling studies for major depressive disorder, with clinical development planned to begin in the second half of 2027. The company is based on research from the University of Helsinki.