Daphne Koller
Founder and CEO
AI drug discovery company combining machine learning with large-scale human and cellular data to find new medicines
insitro is a South San Francisco-based drug discovery company founded and led by AI pioneer Daphne Koller. Since 2018 it has built a large integrated multi-modal corpus of human and cellular data, the Virtual Human AI engine that models how disease begins and progresses, and the TherML platform that designs medicines against the causal drivers it identifies. insitro has partnered with large biopharma companies including Gilead (2019) and Bristol Myers Squibb (2020). On October 15, 2026 it announced a worldwide exclusive research collaboration with AstraZeneca to discover novel targets and therapeutics in MASH and cardiomyopathies, with $40 million upfront and up to approximately $1.46 billion in potential milestones plus royalties.
Founder and CEO