Cisterna Biologics
High quality mRNA for therapeutic application
About
Founded in 2022 and based in San Diego, California, Cisterna Biologics is a technology company. It aims to solve some of the challenges currently facing the biotech industry to develop mRNA-based therapeutics – quality, quantity, longevity and cost of mRNA. As mRNA technology matures, it becomes imperative that these issues are solved so we can fully explore mRNA's endless possibilities as a therapeutic. Cisterna uses proprietary technologies to either remove a contaminant at its source or replace the source itself. For example, to remove double-stranded RNA (dsRNA), we use ribozymes - molecular scissors - to precisely cut the mRNA at its 3’ end. This assures not only 3’ homogeneity, but also eliminates dsRNA, which are primarily produced due to self-templated additions at the 3’ end. Utilizing a PCR-like system to amplify the DNA template in large quantities eliminates the requirement for plasmid enrichment in bacteria, the prime source of endotoxin contamination. These are just a few examples of Cisterna’s powerful technologies being used to achieve our goal of 10x higher quality mRNA for therapeutic application. Cisterna Biologics is a Y Combinator company (Summer 2022). YC-listed status: Active.
- Website
- cisternabx.com
- Location
- San Diego, CA, USA
- Added via
- web
- Ownership
- unclaimed
Where to go
Products
- Cisterna Biologics — Custom high-purity mRNA and RNA synthesis using proprietary SPECC technology that eliminates dsRNA and other product impurities. · Service
Links
- Y Combinator profileycombinator