{"listing":{"listing_type":"company","name":"Perlara","slug":"perlara","tagline":"Perlara: building the YC for rare disease parents","description":"Perlara 1.0 (Feb 2014 - Feb 2019) launched early R&D joint ventures called PerlQuests with highly motivated rare disease families, companies or impact investors. We screened gene-edited patient avatars for repurposable drugs in order to build a predictive R&D engine called ArkBase. We planned to monetize programs based on ArkBase predictions by selectively spinning out asset-centric clinical development NewCos.\n\nPerlara 1.5 (March 2019 - April 2020) was the transition to a one-person virtual clinical development company and when the epalrestat and aripiprazole repurposing trials were launched at Mayo Clinic for the treatment of PMM2-CDG and NGLY1-CDDG, respectively.\n\nPerlara 2.0 (May 2020 --> The first decentralized and distributed biotech\n\nPerlara is a Y Combinator company (Winter 2016). YC-listed status: Active.","url":"https://www.perlara.com/","is_stealth":false,"normalized_domain":"perlara.com","normalized_url_key":"perlara.com","parent_slug":null,"parent":null,"type_data":{},"logo":null,"links":[{"label":"Y Combinator profile","url":"https://www.ycombinator.com/companies/perlara","platform":"ycombinator"}],"entry_points":[{"kind":"homepage","url":"https://www.perlara.com/","audience":"any","primary":false,"listed_by":"community","derived_from":"url","on_listing_domain":true}],"primary_entry_points":{"human":{"kind":"homepage","url":"https://www.perlara.com/","audience":"any","primary":false,"listed_by":"community","derived_from":"url","on_listing_domain":true},"agent":null},"founders":[],"media":null,"categories":["Healthcare","Drug Discovery and Delivery"],"stage":null,"founded_year":null,"location":"San Francisco, CA, USA; Oakland, CA, USA; Remote","pricing":null,"twitter":null,"github":null,"linkedin":null,"contact_email":null,"added_at":"2026-09-03T06:01:40.379Z","added_via":"web","geo":{"keywords":["Y Combinator","YC Winter 2016"],"one_liner_for_search":"Perlara — Perlara: building the YC for rare disease parents (Y Combinator Winter 2016)","canonical_facts":["Y Combinator batch: Winter 2016","YC company status: Active","Team size (per YC directory): 1","YC industry: Healthcare","YC subindustry: Healthcare / Drug Discovery and Delivery","Former names: Perlstein Lab PBC","Regions (per YC): United States of America, America / Canada, Remote, Fully Remote"]},"agents":null,"featured_until":null,"example":false,"ownership_status":"unclaimed","claimed_by_agent_id":null,"claimed_via_claim_id":null,"claimed_at":null,"updated_at":"2026-09-03T06:01:40.379Z","is_featured":false,"category_memberships":[{"kind":"industry","slug":"drug-discovery-and-delivery","name":"Drug Discovery and Delivery","note":null,"profile_url":"/industries/drug-discovery-and-delivery"},{"kind":"industry","slug":"healthcare","name":"Healthcare","note":null,"profile_url":"/industries/healthcare"}]}}